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ZHAWx: CELL Cell cultivation techniques: An introduction

Cell cultivation techniques: An introduction


ZHAWx
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About This Course

Over the past 20 years, many aspects of cell cultivation techniques have become increasingly important. Today, animal and human cell cultures are used to produce antibodies to treat cancer and autoimmune and inflammatory diseases. In addition, these cells are of interest for vaccine production and gene therapies. The current focus is on sustainability; therefore, plant cell and tissue cultures have recently been used in commercial products, active ingredients in cosmetics, and food additives, and they are also used to make therapeutic enzymes. That, however, is not all. Human stem cell-based therapies and human on-chip models for testing cancer drugs and therapies are becoming more and more attractive. Our course will provide you with a solid foundation in how to successfully cultivate the most commonly used cells for these applications. It will prepare you for the practice when you are handling these cells in the laboratory and at the same time will help you to better understand the language/concepts used by cell culture technologists. The focus will be on Chinese hamster ovary cells - CHO cells for short, mesenchymal stem cells, and plant suspension cultures.

What you will learn

- Types, design, and operation of bioreactors - Process modes used in biotechnology - Characterization and evaluation of cultivation systems - Fundamentals of cell biology - Metabolism of mammalian, stem, and plant cells - Cultivation media and additives - Routine working techniques in the laboratory - Process scale-up and optimization - Products and clinical application of stem cells

Prerequisites

The course requires a basic understanding of biological and technical processes. It is designed for interested learners who have little to no experience in the cultivation of different types of cell cultures.

Course Staff

Regine Eibl

Regine Eibl

Prof. Dr. Ing., Lecturer and Head Cell Cultivation Techniques

Regine Eibl has held an engineering degree in “Biotechnology” since 1987 and a Ph.D. in biotechnology from the Technical University in Köthen (Germany) in 1990. She brings more than 20 years of professional expertise in cell culture-based upstream process development, scaling-up, project and team management, and fundraising. Her main products of interest are biopharmaceuticals, cell therapeutics, and plant cell culture-based products. Regine Eibl collaborated and collaborates with numerous well-known companies in Switzerland and abroad (e.g., Bayer, Givaudan, Hoffmann-La Roche, Lonza, Nestlé, Sartorius, ThermoFisher Scientific).

Course Staff

Rüdiger Maschke

Rüdiger Maschke

Dipl.-Ing., Research Associate

Rüdiger Maschke studied chemical engineering with a specialization in bioprocess engineering at the TU Dresden in Germany. His interests lie in the cultivation of microorganisms, plant, and animal cells, and the characterization and optimization of bioreactors. He is a research associate at the ZHAW and conducts research as well as teaching in these areas.

Course Staff

Valentin Jossen

Valentin Jossen

Dr. Ing. ZHAW School of Life Science and Facility Management

Valentin Jossen holds a Ph.D. in process engineering from the Technical University of Berlin. Dr. Jossen is working on various research and development projects in cell therapeutics. His focus is on the development of new bioreactor concepts for the in vitro production of cell therapeutics and the modelling of such systems/processes. p>

Course Staff

Stefan Seidel

Stefan Seidel

MSc Applied Computational Life Sciences, Research Assistant

Stefan Seidel holds a Bachelor’s degree in Biotechnology and a Master’s degree in Applied Computational Life Sciences from ZHAW. He is currently a Ph.D. candidate at TU Berlin and a research assistant at the Institute of Chemistry and Biotechnology at the Zurich University of Applied Sciences. In addition to teaching in the Bachelor's and Master's programs, he works on various research and development projects in the field of biochemical engineering and cell cultivation techniques. His focus is on classical process engineering characterization as well as Computational Fluid Dynamic (CFD) simulations and their validation using Shadowgraphy and Particle Image Velocimetry (PIV) measurements. p>

Course Staff

Cedric Schirmer

Cedric Schirmer

MSc Bioprocess Engineering, Research Associate and Deputy Head Cell Cultivation Technique

Cedric Schirmer has a bachelor's degree in biotechnology from the Berliner Hochschule für Technik (Germany) and a master's degree in bioprocess engineering from the Hamburg University of Technology (Germany). His expertise is in the field of process engineering and the characterisation as well as the development of bioreactors. Furthermore, he deals with the cultivation of bacteria, animal cell cultures as well as stem cells and the scale-up of these cultivations up to the pilot scale. He is a research associate at the center for biochemical engineering and cell cultivation technique and deputy head of the section for cell cultivation technique at the ZHAW. He is doing research and teaching in these areas. p>

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  1. Course Number

    CELL

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  3. Classes End

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